Many biologists assume, as Darwin did, that natural selection acts mainly on late embryonic or postnatal development. This view is consistent with von Baer's observations of morphological divergence at late stages. It is also suggested by the conserved morphology and common molecular genetic mechanisms of pattern formation seen in embryos. I argue here, however, that differences in adult morphology may be generated at a variety of stages. Natural selection may have a major action on developmental mechanisms during the organogenetic period, (...) because this is when many adult traits are specified. Evolutionary changes in these early developmental mechanisms probably include subtle shifts in the timing of gene expression. Changes of this kind have little or no gross effect on the anatomy of the embryo; they are only phenotypically expressed, or readily detected, when amplified at later stages. The phylotypic stage, the developmental hourglass, modularity, and von Baerian divergence are reassessed in terms of these arguments. BioEssays 21:604–613, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

This paper describes the application of eight statistical and machine-learning methods to derive computer models for predicting mortality of hospital patients with pneumonia from their findings at initial presentation. The eight models were each constructed based on 9847 patient cases and they were each evaluated on 4352 additional cases. The primary evaluation metric was the error in predicted survival as a function of the fraction of patients predicted to survive. This metric is useful in assessing a model’s potential to assist (...) a clinician in deciding whether to treat a given patient in the hospital or at home. We examined the error rates of the models when predicting that a given fraction of patients will survive. We examined survival fractions between 0.1 and 0.6. Over this range, each model’s predictive error rate was within 1% of the error rate of every other model. When predicting that approximately 30°K of the patients will survive, all the models have an error rate of less than 1.5%. The models are distinguished more by the number of variables and parameters that they contain than by their error rates; these differences suggest which models may be the most amenable to future implementation as paper-based guidelines. (shrink)

To accept that cognition is embodied is to question many of the beliefs traditionally held by cognitive scientists. One key question regards the localization of cognitive faculties. Here we argue that for cognition to be embodied and sometimes embedded, means that the cognitive faculty cannot be localized in a brain area alone. We review recent research on neural reuse, the 1/f structure of human activity, tool use, group cognition, and social coordination dynamics that we believe demonstrates how the boundary between (...) the different areas of the brain, the brain and body, and the body and environment is not only blurred but indeterminate. In turn, we propose that cognition is supported by a nested structure of task-specific synergies, which are softly assembled from a variety of neural, bodily, and environmental components (including other individuals), and exhibit interaction dominant dynamics. (shrink)

As the team in this volume shows through groundbreaking research, surveys, interviews, and vignettes, death awareness has grown strong, and has changed the way ...

Bad jokes are not simply non-humorous texts. They are texts that are humorous for someone––their author at least––but not for their audience. Bad jokes thus involve a contextual––pragmatic––dimension that is neglected in the semantic theories of humor. In this paper, we propose an approach to humor based on the Aristotelian notion of surprising enthymemes. Jokes are analyzed as kinds of arguments, whose tacit dimension can be retrieved and justified by considering the “logic” on which it is based. However, jokes are (...) based on specific pragmatic conditions: they are regarded as arguments grounded on a generalization that is at the same time uncommon, retrievable, and acceptable or plausible for the audience. This perspective integrates the “local logic” of jokes within a broader rhetorical theory that ultimately rests on the communicative notion of common ground. (shrink)

In this paper I argue that the cognitive system is best viewed as a continuum of cognitive processing from modules to central systems rather than having these as discrete and wholly different modes of cognitive processing. I rely on recent evidence on the development of theory of mind (ToM) abilities and the developmental disorder of autism. I then turn to the phenomenology of modular processes. I show that modular outputs have a stronger force than non-modular or central system outputs. I (...) then evaluate social cognitions and show them to occupy a middle ground with respect to phenomenal strength between modular and non-modular outputs. The evidence presented then seems to indicate a continuum of cognitive processing rather than the traditional division between modules and central systems. (shrink)

Plato and the eternal forms -- Wittgenstein and the end of philosophy -- Kant and the leap of faith -- Nietzsche and the death of God -- Aristotle and public virtue -- Heidegger and authenticity.

In this dissertation I argue for a wider and more robust notion of the modularity of mind thesis. The developmental disorder of autism is the prime analytic tool for developing this approach. I argue that a variety of other approaches are deeply flawed in that they cannot account for the autistic spectrum disorder. I mean by this the autistic profile of deficits such as the lack of social interaction and the avoidance of social contact. I begin with Fodorian modularity. I (...) argue that autism presents us with a case that threatens the division Fodor has between modules and central systems. The autistic disorder exemplifies an area of higher cognition that has many of the properties commonly associated with modular processing. Since Fodor cannot opt for a modular account of theory of mind it must be that his account of central systems is incorrect. I next argue that Baron-Cohen's amended modular architecture cannot explain autism since the autistic deficit cannot be due to a defective module for processing intentional action. Furthermore, his use of modularity threatens to make his view of cognition incoherent. Finally I take up Gopnik and Meltzoff's approach that eschews any type of modularity and instead posits a general learning mechanism. If autism, as they claim, were a general theory-building problem, then one should expect to see other behavioral deficits in other areas of autistic cognition. We do not. I then offer an alternative version of modularity inspired by Karmiloff-Smith . It gives us advantages. On Karmiloff-Smith's account we would expect the autistic deficit to have more perceptually basic components and recent research is bearing this out. Progressive modularity also provides us with a framework in which to understand the ways autistic persons understand the social world. This approach also seeks to unify the cognitive work being done on development with burgeoning work on development in neuroscience. (shrink)

Introduction : saving liberal democracy from itself -- Individualism versus individuality -- Interference, independence, and what's worth doing -- Autonomy -- Freedom, rights, and conflicts between values -- Ethics and rules -- Exploring consequences -- The ethical point of view -- Objective ethics : the good -- Objective ethics : the right -- Negotiating ethically -- Why think ethically? -- Ethical heroism -- Afterword.

The original evidence advanced to support the Tensed S Condition (TSC) and the Specified Subject Condition (SSC) in Chomsky's Conditions on Transformations is reconsidered and viable alternatives to these constraints are provided. It is shown that TSC and SSC, in some instances, lead to a loss of linguistically significant generalization. Satisfactory alternatives can account for the relevant range of data and provide a more general account of additional data. Finally, counterevidence to Subjacency and Superiority is adduced, but explicit alternatives to (...) these conditions are not offered. (shrink)

The need to choose between good things in conflict lies at the heart of politics. Only citizens deliberating together can authoritatively form the democratic public judgment necessary to resolve such conflicts. The key step to arriving at a sound widely supported public judgment is getting all members of the public to “comprehend”---to understand and appreciate---the goods in conflict. Mutual comprehension enables us to combine our individual perspectives without loss, thereby providing the basis for collective deliberation. Such comprehension is essential because (...) the mutual respect between citizens upon which democratic politics depends is impossible without it. Mutual comprehension is possible because we share a common human nature that, despite our manifest and irreducible differences is built around a limited and universal set of human needs and dispositions. (shrink)

The release of genetically engineered organisms into the shared environment raises scientific, ethical, and societal issues. Using some form of democratic deliberation to provide the public with a voice on the policies that govern these technologies is important, but there has not been enough attention to how we should connect public deliberation to the existing regulatory process. Drawing on lessons from previous public deliberative efforts by U.S. federal agencies, we identify several practical issues that will need to be addressed if (...) relevant federal agencies are to undertake public deliberative activities to inform decision‐making about gene editing in the wild. We argue that, while agencies may have institutional capacity to undertake public deliberative activities, there may not be sufficient political support for them to do so. Advocates of public deliberation need to make a stronger case to Congress about why federal agencies should be encouraged and supported to conduct public deliberations. (shrink)

This paper develops twenty hypotheses concerning the relationships among selected individual differences variables (locus of control, delay of gratification, gender, and race) and five different ethical beliefs. The results of a study of collegians provide support for seventeen out of twenty research hypotheses. As predicted, locus of control, delay of gratification, and race are related to ethical beliefs. Also as predicted, gender is not related to ethical beliefs.

Two visual world experiments investigated the processing of the implicature associated with some using a “gumball paradigm.” On each trial, participants saw an image of a gumball machine with an upper chamber with orange and blue gumballs and an empty lower chamber. Gumballs dropped to the lower chamber, creating a contrast between a partitioned set of gumballs of one color and an unpartitioned set of the other. Participants then evaluated spoken statements, such as “You got some of the blue gumballs.” (...) Experiment 1 investigated the time course of the pragmatic enrichment from some to not all when the only utterance alternatives available to refer to the different sets were some and all. In Experiment 2, the number terms two, three, four, and five were also included in the set of alternatives. Scalar implicatures were delayed relative to the interpretation of literal statements with all only when number terms were available. The results are interpreted as evidence for a constraint-based account of scalar implicature processing. (shrink)

Hierarchies abound to help us organize our world. A hierarchy places items into a general order, where more ‘general’ is also more ‘abstract’. The etymology of hierarchy is grounded in notions of religious and social rank. This article, after a historical review, focuses on knowledge systems, an interloper of the term hierarchy since at least the 1800s. Hierarchies in knowledge systems include taxonomies, classification systems, or thesauri in information science, and systems for representing information and knowledge to computers, notably ontologies (...) and knowledge representation languages. Hierarchies are the logical underpinning of inference and reasoning in these systems, as well as the scaffolding for classification and inheritance. Hierarchies in knowledge systems express subsumption relations that have flexible variants, which we can represent algorithmically, and thus computationally. This article dissects that variability, leading to a proposed typology of hierarchies useful to knowledge systems. The article argues through a perspective informed by Charles Peirce that natural hierarchies are real, can be logically determined, and are the appropriate basis for knowledge systems. Description logics and semantic language standards reflect this perspective, importantly through their open-world logic and vocabularies for generalized subsumption hierarchies. Recent research suggests possible mechanisms for the emergence of natural hierarchies. (shrink)

Lex Luthor despises Superman. He obsesses about Superman. He tries to kill Superman. Luthor takes existentialism to the extreme, though, rejecting ethics and becoming an anti‐hero. In Superman: Secret Origin, Luthor is presented as self‐directed from an early age. Friedrich Nietzsche can help us understand Luthor as an iconoclast, literally one who breaks sacred images. Luthor also explains why he is so obsessed with bringing down Superman. Luthor thinks that Superman interferes with people viewing their lives as an existential project. (...) Lex Luthor underscores the complexities of existentialist philosophy. While he is creative, self‐determined, and autonomous, he is also completely immoral. His willingness to sacrifice anything or anyone takes existentialism to an extreme that Nietzsche, Sartre, and Kierkegaard would reject. And so, we are left to wonder: is Lex Luthor an evil genius and an abomination to existentialism, or might he be a true evolution of what existentialism can become. (shrink)

In Aaron and Bachalo's work, Doctor Stephen Strange exemplifies the characteristics and methods of the natural philosophers in clashes with his mystical enemies, Lord Imperator and the Empirikul. It's easy to be distracted by Doctor Strange's fancy spells, unique job title, or flashy cape, but we should also recognize that he is a Sorcerer Supreme, who demonstrates both discipline and intellect. Like the historical philosopher‐scientists, Doctor Strange studies metaphysics and its relationship to the physical world. When intellectuals began to challenge (...) Aristotle's teleological world‐view, they faced opposition from both the Catholic Church, who found Aristotle's views consistent with scripture, and the scientific community. Historian Peter Dear's book Revolutionizing the Sciences helps situate the work of ancient philosophers, like Aristotle, in the context of the history of the scientific revolution. (shrink)

Three experiments investigated the processing of the implicature associated with some using a “gumball paradigm.” On each trial, participants saw an image of a gumball machine with an upper chamber with 13 gumballs and an empty lower chamber. Gumballs then dropped to the lower chamber and participants evaluated statements, such as “You got some of the gumballs.” Experiment 1 established that some is less natural for reference to small sets and unpartitioned sets compared to intermediate sets. Partitive some of was (...) less natural than simple some when used with the unpartitioned set. In Experiment 2, including exact number descriptions lowered naturalness ratings for some with small sets but not for intermediate size sets and the unpartitioned set. In Experiment 3, the naturalness ratings from Experiment 2 predicted response times. The results are interpreted as evidence for a Constraint-Based account of scalar implicature processing and against both two-stage, Literal-First models and pragmatic Default models. (shrink)

Since Horn (1972) the notion of conversational implicature proposed by Grice has been put to use to explain certain interpretive differences between expressions in natural language and their counterparts in formal logic. For example, the sentences in (1) seem to convey more than they would be expected to if the natural language disjunction or had the same meaning as the logical disjunction ∨, or if the quantificational determiner some was interpreted as the existential quantifier ∃.

According to contemporary representationalism, phenomenal qualia—of specifically sensory experiences—supervene on representational content. Most arguments for representationalism share a common, phenomenological premise: the so-called “transparency thesis.” According to the transparency thesis, it is difficult—if not impossible—to distinguish the quality or character of experiencing an object from the perceived properties of that object. In this paper, I show that Husserl would react negatively to the transparency thesis; and, consequently, that Husserl would be opposed to at least two versions of contemporary representationalism. First, (...) I show that Husserl would be opposed to strong representationalism, since he believes the cognitive content of a perceptual episode can vary despite constancy of sensory qualia. Second, I then show that Husserl would be opposed to weak representationalism, since he believes that sensory qualia—specifically, the sort that he calls “kinesthetic sensations”—can vary despite constancy in representational content. (shrink)

As an incredibly diverse religious system, Buddhism is constantly changing. The Oxford Handbook of Contemporary Buddhism offers a comprehensive collection of work by leading scholars in the field that tracks these changes up to the present day. Taken together, the book provides a blueprint to understanding Buddhism's past and uses it to explore the ways in which Buddhism has transformed in the twentieth and twenty-first centuries. The volume contains 41 essays, divided into two sections. The essays in the first section (...) examine the historical development of Buddhist traditions throughout the world. These chapters cover familiar settings like India, Japan, and Tibet as well as the less well-known countries of Vietnam, Bhutan, and the regions of Latin America, Africa, and Oceania. Focusing on changes within countries and transnationally, this section also contains chapters that focus explicitly on globalization, such as Buddhist international organizations and diasporic communities. The second section tracks the relationship between Buddhist traditions and particular themes. These chapters review Buddhist interactions with contemporary topics such as violence and peacebuilding, and ecology, as well as Buddhist influences in areas such as medicine and science. Offering coverage that is both expansive and detailed, The Oxford Handbook of Contemporary Buddhism delves into some of the most debated and contested areas within Buddhist Studies today. (shrink)

Since 1980, the number of twin births in the United States has increased 76 percent, and the number of triplets or higher-order multiples has increased over 400 percent. These increases are due in part to increased maternal age, which is associated with spontaneous twinning. But the primary reason for these increases is that more and more people are undergoing fertility treatment. Despite an emerging (but not absolute) consensus in the medical literature that multiples, including twins, should be a far less (...) frequent outcome of fertility treatment, American clinicians currently practice fertility medicine in ways likely to result in twins and, occasionally, triplets-often, they tell us, at the request of their patients. At first blush, one might conclude that these practice patterns show that patients and their doctors have weighed the risks associated with twins against the benefits of swiftly completing their families and decided that the risks are worth taking. That is, their requests for twins must represent their free and informed choices. But there are reasons to be skeptical of this interpretation, including that the preferences of many patients seem to be very strongly shaped, if not sometimes completely constrained, by concerns about costs-costs that mainly result from the routine exclusion of in vitro fertilization from health insurance coverage. It is quite possible, we believe, that these cost concerns actually undermine the autonomy of fertility patients, pushing many of them to take risks with their health and the health of their hoped-for future children. [ABSTRACT FROM AUTHOR]. (shrink)

Many older people need external support for their daily living. A large minority of older adults with low or modest pension incomes face financial strains from the high cost of illness, and many older people in urban areas live in social isolation. Indeed, population aging has become a policy topic of concern. The policy debate since the end of the twentieth century about the future of public pensions and health and long‐term care programs has increasingly framed the growing numbers of (...) older people in alarmist terms. Unfounded claims about the unaffordability and unsustainability of social policies supporting older people have become common currency, often disguised as concerns about intergenerational justice. Such claims and concerns hinder clear thinking about proper social and fiscal policies, housing, health care, and labor markets to safeguard the well‐being of older people in aging societies. (shrink)

Recently, a number of epistemologists have argued that there are no non-conceptual elements in representational content. On their view, the only sort of non-conceptual elements are components of sub-personal organic hardware that, because they enjoy no veridical role, must be construed epistemologically irrelevant. By reviewing a 35-year-old debate initiated by Dagfinn F.

Is it ever fair to limit treatment for diseases like glioblastoma for which prognosis is poor? Because resources are finite and health care spending limits the other possible uses for those resources, limiting access to an intervention that does not generate benefits is ethically sound. Ignoring the balance of benefits and burdens associated with treatment ignores opportunity costs and leads us to treat some lives as more valuable than others. Although it is ethically sound to set limits on medical care, (...) I argue that biological age is a poor criterion for allocating resources. (shrink)

Is it ever fair to limit treatment for diseases like glioblastoma for which prognosis is poor? Because resources are finite and health care spending limits the other possible uses for those resources, limiting access to an intervention that does not generate benefits is ethically sound. Ignoring the balance of benefits and burdens associated with treatment ignores opportunity costs and leads us to treat some lives as more valuable than others. It also ignores evidence that patients and families, when presented with (...) adequate information about the benefits and burdens of aggressive treatment compared with palliative care, often prefer the palliative care option.Should the limitations we set on the availability of care be greater for older people than younger people? Since the 1980s, scholars have called for strong age rationing of medical care in which Medicare would not pay for anything other than palliative care after they have achieved average life expectancy. (shrink)

I present an original model in judgment aggregation theory that demonstrates the general impossibility of consistently describing decision-making purely at the group level. Only a type of unanimity rule can guarantee a group decision is consistent with supporting reasons, and even this possibility is limited to a small class of reasoning methods. The key innovation is that this result holds when individuals can reason in different ways, an allowance not previously considered in the literature. This generalizes judgment aggregation to subjective (...) decision situations, implying that the discursive dilemma persists without individual agreement on the logical constraints. Notably, the model mirrors the typical method of choosing political representatives, and thus suggests that no voting procedure other than unanimity rule can guarantee representation that reflects electorate opinion. Finally, I apply the results to a normative argument for unanimity rule in contract theory and juries, as well as to problems posed for deliberative democratic theory and the concept of representation. (shrink)

A Kantian evaluation of Taylorism in the workplace requires a consideration of four problems; (1) the conditions of agency, (2) the relation of Taylorism to these conditions, (3) an explanation of the method given by the Typic for applying the Categorical Imperative, and (4) the actual application of the Categorical Imperative to Taylorism. An agent who views himself as a performer is distinguished from an agent who is a mere observer of his own actions, and it is argued that Taylorism (...) in effect attempts to remove the purposiveness of action from the workmen and to reduce them to the state of being mere observers of their own actions. Then it is argued that in order for one to attempt to think of a maxim as a universal law, one must posit a universal and necessary connection between the circumstances and the performances and then another such connection between the action and the purpose to be achieved. A model is constructed using heat-seeking machines, and it is argued that a principle analogous to Taylorism could not hold as a universal law for such machines. Thus, Taylorism is not an acceptable solution to the problem of coordinating the activities of self-directed agents within the workplace. (shrink)

An agent is one who regulates his/her own actions through positive and negative feedback. It is painful for a rational being to set himself a task and then find himself unable to complete it entirely as he/she conceives it. To escape this pain, a person may use self-deception to avoid such negative feedback. When this denial becomes universalized, an agent can no longer function as a self-regulating, cybernetic system, i.e., as an agent who directs his/her own actions. Ten types of (...) moral self-deception are distinguished, and the duty of moral self-knowledge is clarified. (shrink)

The aging of attentional and emotional functions has been extensively studied but relatively independently. Therefore, the relationships between aging and the interactions of attentional and emotional processes remain elusive. This study aimed to determine how age affected the interactions between attentional and emotional processes during adulthood. One-hundred forty adults aged 18–79 performed the emotional variant of the Attention Network Test, which probed alerting, orienting, and executive control in the presence and absence of threatening faces. During this task, contexts with varying (...) levels of task preparatory processes were created to modulate the effect of threatening faces on attention, and functional near-infrared spectroscopy (fNIRS) was used to examine the neural underpinnings of the behavioural effects. The behavioural results showed that aging was associated with a significant decline in alerting efficiency, and there was a statistical trend for age-related deficits in executive control. Despite these age differences, age did not significantly moderate the interactions among attentional networks or between attention and emotion. Additionally, the fNIRS results showed that decreased frontal cortex functioning might underlie the age-related decline in executive control. Therefore, while aging has varying effects on different attentional networks, the interactions of attentional and emotional processes remain relatively unaffected by age. (shrink)